许丽霞，女，住院医师，博士，2008年毕业于中山临床医学系，获医学学士学位，同年被推荐免试到中山附属医院消化内科攻读硕士研究生，硕士期间赴香港中文威尔斯亲王医院消化疾病研究所做访问学者；2014年于香港中文内科及药物治疗系获博士学位，主要研究方向为消化系统肿瘤（胃癌、结直肠癌、肝癌）的发病机制；博士期间赴澳洲国立做访问学者，师从国际肝病医生Geoff Farrell 教授。对消化系统常见疾病（包括慢性胃炎、消化性溃疡、慢性肝病、功能性胃肠病等），尤其是消化系统肿瘤的诊断与治疗有一定的临床经验。业绩：迄今为止共发表学术论文十多篇，其中包括以作者身份在Gut等专业国际学术期刊发表的论文2篇；多次在消化领域全球别学术会议DDW口头汇报研究成果；获得专利一项；2015年入选中山附属医院“青年人才支持计划”。代表性论著：1.许丽霞，曾志荣，吴小琴，等。基质金属蛋白酶-9基因多态性与广东地区胃癌的关系。胃肠病学. 2010; 15(12):713-6。2.许丽霞，曾志荣，于君。肿瘤控制基因启动子区甲基化在胃癌中的功能意义及临床价值。中华消化杂志. 2011; 31(4):286-88。3.曾志荣，吴小琴，许丽霞，等。白细胞介素-17F A7488G多态性与广东地区胃癌的关系。中华消化杂志. 2010; 30(8):507-11。4.Xu L, Li X, Chu ES, et al. Epigenetic inactivation of BCL6B, a novel functional tumour suppressor for gastric cancer, is associated with poor survival of gastric cancer. Gut 2012; 61(7):977-85. 5.Xu L, Li X, Cai M, et al. Increased expression of Solute carrier family 12 member 5 via gene amplification contributes to tumour progression and metastasis and associates with poor survival in colorectal cancer. Gut Accepted. 6.Xu L, Zeng Z, Chen B, et al. Association between the TGFB1-509C/T and TGFBR2-875A/G polymorphisms and gastric cancer: a case-control study. Oncol Lett. 2011; 2:371-7. 7.Wang J, Dong L, Xu L, et al. B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice. Cancer Lett 2014,355(2):192-200. 8.Wu X, Zeng Z, Xu L, et al. Increased expression of IL17A in human gastric cancer and its potential roles in gastric carcinogenesis. Tumor Biol 2014,35(6):5347-56. 9.Yang Q, Gao J, Xu L, et al.?Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer. Biomarkers 2013; 18(8):721-5. 10.Zhao G, Xu L, Chu SH, et al. Establishment of an orthotopic transplantation tumor model of hepatocellular carcinoma in mice. World J Gastroenterol 2012,18(47):7087-92. 11.Chen B, Zeng Z, Xu L, et al. IL23R +2199A/C polymorphism is associated with decreased risk of certain subtypes of gastric cancer in Chinese: A case-control study. Cancer Epidemiol 2011;35(2):165-9. 12.Liu W, Li X, Chu ES, et al. Paired box gene 5 is a novel tumor suppressor in hepatocellular carcinoma through interaction with p53 signaling pathway. Hepatology 2011;53(3):843-53. 13.Yu C, Yu J, Yao X, et al. Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing. Cell Res 2014 Jun;24(6):701-12. 14.Otani K, Dong Y, Li X, et al. Odd-skipped related 1 is a novel tumor suppressor gene and a potential prognostic biomarker in gastric cancer. J Pathol 2014,234(3):302-15. 15.Jiang L, Yang YD, Fu L, et al. CLDN3 inhibits cancer aggressiveness via Wnt-EMT signaling and is a potential prognostic biomarker for hepatocellular carcinoma. Oncotarget 2014 Sep 15;5(17):7663-76.
