胡文献，男，副主任医师，浙江肿瘤学硕士生导师、医学博士，浙江医学院附属邵逸夫医院副主任医师。曾在的癌症研究中心安德森癌症中心（M.D. Anderson Cancer Center）从事恶性肿瘤的临床基础研究近3年。对肿瘤外科疾病（乳腺肿瘤、甲状腺肿瘤）的微创手术及综合治疗等有丰富的临床经验。1998年-2002年 杭州市其次患者医院普外科2002年-2009年 浙江医学院肿瘤学硕士博士连读2006年-2008年的癌症中心----安德森癌症中心（M.D. Anderson Cancer Center）从事医学临床基础研究2009年-至今 浙江医学院附属邵逸夫医院肿瘤外科 主攻方向：肿瘤外科 （乳腺肿瘤、胃肠肿瘤及甲状腺软组织肿瘤）医生擅长：乳腺肿瘤、胃肠肿瘤及甲状腺软组织肿瘤的外科治疗和综合治疗。尤其对乳腺癌化疗耐药机制、胃癌及结肠癌的新辅助化疗预测及微创手术等有较深入地研究。医疗成果：已发表论文近20余篇，SCI收录论文12篇。其中以作者和通讯作者身份发表的SCI论文6篇，较高影响因子为6.747分。作为主持人承担了自然科学青年基金1项和钱江人才计划项目1项，同时作为主要参与者承担课题1项及浙江省自然科学基金核心项目1项等。主要论文：1. Kenzhen Lv,?Liqun Liu, Linbo Wang, Jiren Yu, Xiaojiao Liu, Yongxia Cheng, Minjun Dong, Rongyue Teng, Linjiao Wu, Peifen Fu, Wuguo Deng, *Wenxian Hu, Lisong Teng. Lin28 Mediates Paclitaxel Resistance by Modulating p21, Rb and Let-7a miRNA in Breast Cancer Cells, PLoS one, 7(7):e40008, 2012. （通讯作者）2. He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One, 7(2):e31087, 2012.3. Yanbin Zhou, Wayne L. Hofstetter, Yong He, Wenxian Hu, Abujiang Pataer, Li Wang, Ji Wang, Yihong Zhou, Liping Yu, Bingliang Fang, Stephen G. Swisher. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer biology & therapy, 9(7):1-7, 2010.4. Wenxian Hu, Wayne L, Hofstetter, Hong Li, Yanbin Zhou, Yong He, Abujiang Pataer, Li Wang, Keping Xie, Stephen G. Swisher and Bingliang Fang. Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma, Clinical Cancer Research, 15(18):5688-5695, 2009.5. Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG. Double-Stranded RNA-Dependent Protein Kinase (PKR)-Dependent Apoptosis Induction by a Novel Small Compound. Journal of Pharmacology and Experimental Therapeutics, 328(3):866-872, 2009.6. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein Kinase. Cancer Gene Therapy, 15(9):616-624, 2008.7. Hu Wenxian, Bartlett David L, Swisher Stephen G, Fang Bingliang. Redirecting adaptive immunity against foreign antigens to tumors for cancer therapy. Cancer biology & therapy, 6(11):1773-1779, 2007.8. Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Molecular Cancer Therapeutics, 7(8):2528-2535, 2008.
